Selenyum Dioksit ve Paklitaksel Kombinasyonunun MDA-MB-231 Meme Kanseri Hücre Hattı Üzerine Etkisinin Değerlendirilmesi
نویسندگان
چکیده
Amaç: Bu çalışmanın amacı, bitkisel kökenli bileşik olan selenyum dioksit (SEL) ile kemoterapötik ilaç paklitaksel’in (PTX) kombine uygulamasının MDA-MB-231 meme kanseri hücre hattı üzerine etkisinin belirlenmesidir.
 Gereç ve Yöntemler: Çalışmamızda öncelikle SEL’in yarı maksimal inhibitör konsantrasyonunun belirlenmesi amacıyla MTT testi yapıldı. Deney grupları SEL1, SEL2, SEL3, PTX, SEL1+PTX, SEL2+PTX SEL3+PTX şeklinde oluşturulduktan sonra apoptoz TUNEL metodu, NF-kB ekspresyonu immunofloresan boyama metodu canlılığı ise analizi gösterildi. 
 Bulgular: hücrelerinde canlılığını azalttığı PTX gruplarında kontrole göre apoptozun arttığı görüldü (p0,999, p>0,999, p=0,725).
 Sonuç: Mevcut çalışmada dizisinde SEL PTX’in antagonistik etkiye sahip oldukları belirlenmiştir.
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ژورنال
عنوان ژورنال: Sa?l?k Bilimlerinde De?er
سال: 2023
ISSN: ['2792-0542']
DOI: https://doi.org/10.33631/sabd.1171222